Understanding how cells internalize their membrane during a specific type of endocytosis
Molecular and biophysical mechanism of plasma membrane internalization during nonclathrin endocytosis
This study is looking at how cells take in materials from their surroundings in a special way that could help us understand cancer better, and it aims to find new clues that might lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10991795 on NIH RePORTER |
What this research studies
This research investigates the molecular and mechanical processes involved in a type of endocytosis called nonclathrin endocytosis, which is important for how cells take in materials from their environment. The study aims to identify unique markers for this process using advanced imaging techniques and machine learning to better understand how cells regulate their membrane dynamics. By examining how membrane tension influences this internalization, the research could provide insights into cellular behaviors relevant to cancer metastasis and other conditions. Patients may benefit from improved understanding of cancer cell behavior and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that exhibit aggressive metastasis and may benefit from targeted therapies.
Not a fit: Patients with non-cancerous conditions or those whose cancer is not characterized by aggressive metastasis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer metastasis and potential therapeutic strategies to inhibit cancer cell movement.
How similar studies have performed: Other research has shown success in using advanced imaging and machine learning techniques to study cellular processes, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Akamatsu, Matthew Sataro — University of Washington
- Study coordinator: Akamatsu, Matthew Sataro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.