Understanding how cells interact with their environment in 3D models
Official title: Implementing the nascent ECM into the dynamic reciprocity of cell-ECM interactions
Funded at University of Pennsylvania · NIH-11019272 · Data updated 2026-11-12
This study is looking at how cells decide what to do based on their surroundings, especially in 3D environments that mimic real tissues, to help improve drug testing and our understanding of how cells behave in the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 22, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $406,250 |
| NIH project number | 1R35GM157063-01 |
| Project ID | NIH-11019272 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to tissue regeneration or developmental disorders.
✕Less likely to help
Patients with stable, non-regenerative conditions may not receive direct benefits from this research.
What this research studies
This research investigates how cells make decisions based on their interactions with the extracellular matrix (ECM) in three-dimensional environments, which are crucial for tissue development and regeneration. By utilizing advanced engineered systems like organoids and organ-on-chip models, the study aims to better replicate the dynamic relationship between cells and their ECM. The goal is to enhance these models to more accurately reflect real tissue conditions, which could lead to improved drug testing and understanding of cellular behavior in complex environments.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug testing methods and better insights into tissue regeneration and development.
How similar studies have gone: Other research has shown promise in using engineered 3D models for studying cell interactions, indicating that this approach has potential for success.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Loebel, Claudia — University of Pennsylvania
- Study coordinator: Loebel, Claudia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.