Understanding how cells interact to shape the colon
How Patterned Mesenchymal-Epithelial interactions Shape Intestinal Crypts
This study is looking at how certain cells in the colon work together to keep our intestines healthy, and it hopes to find new ways to understand and improve treatments for colon cancer and other gut issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11010779 on NIH RePORTER |
What this research studies
This research investigates the interactions between mesenchymal and epithelial cells in the colon, which are crucial for maintaining healthy intestinal structures. By using advanced techniques like single-cell RNA sequencing and genetically modified mouse models, the study aims to uncover the molecular mechanisms that guide the development and regeneration of colonic crypts. Patients may benefit from insights gained about how these interactions can influence conditions like colon cancer and other intestinal diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the colon, particularly those over 21 years old.
Not a fit: Patients with non-colonic diseases or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases of the colon.
How similar studies have performed: Previous research has shown promising results in understanding cell interactions in other tissues, suggesting potential for success in this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Klein, Ophir D — University of California, San Francisco
- Study coordinator: Klein, Ophir D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.