Understanding how cells interact at their surfaces in 3D structures
Official title: Unveiling Functional Roles of Apical Surface Interactions Between Opposing Cell Layers
Funded at University of Washington · NIH-10890595 · Data updated 2026-11-12
This study is looking at how different layers of cells in tissues work together and respond to changes, using a special technique to measure the forces between them, which could help us learn more about how our bodies function and how diseases develop.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $441,250 |
| NIH project number | 5R35GM149516-02 |
| Project ID | NIH-10890595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting tissue structures, such as vascular diseases or developmental disorders.
✕Less likely to help
Patients with conditions unrelated to cell adhesion or tissue architecture may not benefit from this research.
What this research studies
This research investigates the interactions between opposing cell layers in three-dimensional tissue structures, which are crucial for understanding how tissues function and respond to various stimuli. The team will use a novel technique called Bilayer Intermolecular Force Microscopy (BIFM) to measure the forces between these cell layers as they come together. By exploring how electrostatic charges and cilia influence these interactions, the research aims to uncover new insights into cell communication and adhesion in tissues. This could lead to a better understanding of various biological processes and diseases.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of tissue architecture and improve treatments for conditions related to cell adhesion and communication.
How similar studies have gone: While the specific approach of measuring apical surface interactions in 3D architectures is novel, similar studies have shown success in understanding cell interactions and their implications in various biological contexts.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Fu, Hongxia — University of Washington
- Study coordinator: Fu, Hongxia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.