Understanding how cells in the cochlea connect to support hearing.
Cellular and Molecular Mechanisms of Cochlear Innervation
['FUNDING_R01'] · GEORGETOWN UNIVERSITY · NIH-10872238
This study is looking at how certain cells in the ear help the nerve cells that are important for hearing connect with tiny hair cells, which is key for good hearing, and it could lead to new ways to help people with hearing problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-10872238 on ClinicalTrials.gov |
What this research studies
This research investigates the cellular and molecular mechanisms that facilitate the connections between spiral ganglion neurons and hair cells in the cochlea, which are essential for hearing. The study focuses on how certain cells, known as otic mesenchyme cells, influence the development and survival of these neurons through specific signaling pathways. By examining the role of transcription factors and other signaling molecules, the research aims to uncover how these connections are formed and maintained, particularly before hearing onset. This could lead to insights into potential treatments for hearing impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have hearing impairments or conditions related to cochlear function.
Not a fit: Patients with normal hearing or those whose hearing loss is not related to cochlear synaptic connections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating hearing loss by enhancing the connections necessary for auditory function.
How similar studies have performed: Previous research has shown promising results in understanding cochlear mechanisms, but this specific approach focusing on otic mesenchyme cells and their signaling pathways is relatively novel.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COATE, THOMAS M — GEORGETOWN UNIVERSITY
- Study coordinator: COATE, THOMAS M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.