Understanding how cells in esophageal cancer resist treatment
Elucidating Novel APE1 Redox-Dependent Functions in Esophageal Adenocarcinoma
['FUNDING_P01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11127390
This work explores how certain cells in esophageal cancer become resistant to treatment and survive, especially in people with Barrett's esophagus.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11127390 on ClinicalTrials.gov |
What this research studies
Esophageal adenocarcinoma, a type of cancer, has become more common, often starting from a condition called Barrett's esophagus. This condition can develop from long-term acid reflux, which causes inflammation and stress in the esophagus. Our team is looking into how cancer cells in the esophagus manage to survive this stress and become resistant to current medications. We are focusing on a specific protein called APE1 and how its activity helps these cancer cells grow and spread.
Who could benefit from this research
Good fit: This foundational work is relevant to patients with Barrett's esophagus or esophageal adenocarcinoma, as it seeks to understand the disease at a cellular level.
Not a fit: Patients without Barrett's esophagus or esophageal adenocarcinoma would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to overcome treatment resistance in esophageal adenocarcinoma and improve outcomes for patients.
How similar studies have performed: Previous work by this team and others has shown that chronic exposure to acidic bile salts increases oxidative stress, which is a known factor in the development of esophageal cancer.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EL-RIFAI, WAEL — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: EL-RIFAI, WAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Barrett Syndrome