Understanding how cells help heal large bone injuries
Official title: Cellular and molecular coordinators of large-scale bone repair
Funded at University of Southern California · NIH-10982004 · Data updated 2026-11-12
This study is looking at how certain cells in the body help heal big bone injuries, using a special mouse model, to find better ways to treat people with serious bone damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 16, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $626,879 |
| NIH project number | 1R01AR083445-01A1 |
| Project ID | NIH-10982004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with severe bone injuries or conditions that impair bone healing.
✕Less likely to help
Patients with minor bone injuries or those whose conditions do not involve significant bone regeneration may not benefit from this research.
What this research studies
This research investigates the cellular and molecular processes involved in repairing extensive bone injuries using a novel mouse model. It focuses on understanding how specific cell populations, particularly those marked by the Sox9 gene, transition from a resting state to an active state in response to injury. The study aims to uncover the mechanisms that trigger these cells to recruit other necessary cells for effective bone regeneration, ultimately leading to the formation of a bone callus across the injury site. By exploring these processes, the research seeks to provide insights that could improve treatments for patients with severe bone injuries.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients suffering from large-scale bone injuries, enhancing their recovery and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding cellular mechanisms of bone repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Mariani, Francesca V — University of Southern California
- Study coordinator: Mariani, Francesca V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.