Understanding how cells handle stress to keep tissues healthy
Elucidating the role of the Integrated Stress Response pathway in tissue homeostasis
This research explores how a natural process called the Integrated Stress Response helps our cells stay healthy and how it might be involved in diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11145028 on NIH RePORTER |
What this research studies
Our bodies have special ways to cope with stress, like when cells don't get enough nutrients or face harmful conditions. One important way is through the Integrated Stress Response (ISR), a pathway that helps cells adapt and survive. While we know the ISR is vital for maintaining healthy tissues, especially in organs like the liver and fat, we don't fully understand the detailed steps of how it works. This project aims to uncover the precise molecular and cellular mechanisms of the ISR, using fruit flies as a model to gain new insights into its role in keeping tissues healthy.
Who could benefit from this research
Good fit: Patients with conditions related to cellular stress or cancer may eventually benefit from the knowledge gained from this foundational research.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how cellular stress contributes to diseases like cancer and potentially identify new targets for future treatments.
How similar studies have performed: While the Integrated Stress Response pathway is known, this research focuses on uncovering the precise molecular and cellular mechanisms of its regulation in tissue health, which are currently not well understood.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Vasudevan, Deepika — University of Pittsburgh at Pittsburgh
- Study coordinator: Vasudevan, Deepika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.