Understanding how cells generate and control their contractile movements
Mechanisms of Contractile Network Assembly
This study is looking at how cells use a special protein called myosin 2 to create and control the forces they need to grow and develop properly, which could help us understand more about how our bodies work and what goes wrong in certain diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project ID | NIH-10899528 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells create and regulate their contractile forces, which are essential for cell and tissue development. Using advanced light microscopy, the team will observe the dynamics of myosin 2, a key protein responsible for generating force in cells, in real-time. The study employs a combination of high-resolution imaging and various cellular assays to explore how these contractile structures are formed, adjusted, and dismantled during cellular processes. By uncovering these mechanisms, the research aims to provide insights into fundamental cellular functions and their implications for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve abnormal cell contractility or tissue morphogenesis.
Not a fit: Patients with stable conditions unrelated to cellular movement or contractility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of cellular movements, potentially informing treatments for conditions related to cell motility and tissue development.
How similar studies have performed: Other research has shown success in understanding cellular mechanics through similar imaging techniques, suggesting that this approach could yield valuable insights.
Where this research is happening
Maywood, United States
- Loyola University Chicago — Maywood, United States (Active)
Researchers
- Principal investigator: Beach, Jordan — Loyola University Chicago
- Study coordinator: Beach, Jordan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.