Understanding how cells form structures during development
Cell cycle dependent mechanisms triggering lumen formation in vivo
This study looks at how tiny cells in developing hearts work together to form important structures, using zebrafish to help us understand what goes wrong in heart development, which could help us learn more about heart defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Syracuse University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10733425 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which ciliated cells develop into functional organs, specifically focusing on the formation of the organ of asymmetry that is crucial for heart development. By studying model organisms like zebrafish, the research aims to uncover how cell division and the placement of cellular structures contribute to the development of these organs. The approach combines cell biology and developmental biology to explore the processes involved in cell division and the subsequent formation of cilia, which are essential for proper organ function. This could provide insights into congenital heart defects and other developmental issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart defects or those interested in the biological mechanisms of heart development.
Not a fit: Patients with fully developed hearts and no congenital defects may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of congenital heart defects and potential new strategies for prevention or treatment.
How similar studies have performed: While some research has explored aspects of cell division and organ development, this specific approach focusing on ciliated cells and their role in heart development is relatively novel.
Where this research is happening
Syracuse, United States
- Syracuse University — Syracuse, United States (Active)
Researchers
- Principal investigator: Hehnly, Heidi — Syracuse University
- Study coordinator: Hehnly, Heidi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.