Understanding how cells form patterns during embryonic development
Official title: Integration of spatiotemporal signaling for pattern formation and scaling
Funded at Northwestern University at Chicago · NIH-11085830 · Data updated 2026-11-12
This study is exploring how tiny building blocks in developing embryos, like those in zebrafish, create the right shapes and patterns for our bones, which could help us understand and prevent certain birth defects related to the spine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $449,499 |
| NIH project number | 7R01HD103623-04 |
| Project ID | NIH-11085830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital abnormalities affecting vertebral formation or those interested in the underlying mechanisms of embryonic development.
✕Less likely to help
Patients with conditions unrelated to embryonic development or vertebral formation may not benefit from this research.
What this research studies
This research investigates the mechanisms behind how tissues and organs develop specific patterns during embryonic growth, focusing on the segmentation of somites, which are precursors to vertebrae. By utilizing a novel 3D culture system of zebrafish, the study examines the role of signaling gradients and oscillatory gene expressions in determining segment lengths and patterns. The researchers aim to uncover how these processes are integrated and how cells interpret the timing and spatial information to form proper structures. This could lead to a better understanding of congenital defects related to vertebral formation.
Why it matters
Potential benefit: If successful, this research could provide insights into preventing or treating birth defects related to vertebral development.
How similar studies have gone: Previous research has shown success in understanding developmental processes through similar approaches, particularly in model organisms like zebrafish and mice.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Ozbudak, Ertugrul M — Northwestern University at Chicago
- Study coordinator: Ozbudak, Ertugrul M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.