Understanding how cells form patterns during embryonic development
Integration of spatiotemporal signaling for pattern formation and scaling
This study is exploring how tiny building blocks in developing embryos, like those in zebrafish, create the right shapes and patterns for our bones, which could help us understand and prevent certain birth defects related to the spine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11085830 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how tissues and organs develop specific patterns during embryonic growth, focusing on the segmentation of somites, which are precursors to vertebrae. By utilizing a novel 3D culture system of zebrafish, the study examines the role of signaling gradients and oscillatory gene expressions in determining segment lengths and patterns. The researchers aim to uncover how these processes are integrated and how cells interpret the timing and spatial information to form proper structures. This could lead to a better understanding of congenital defects related to vertebral formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities affecting vertebral formation or those interested in the underlying mechanisms of embryonic development.
Not a fit: Patients with conditions unrelated to embryonic development or vertebral formation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into preventing or treating birth defects related to vertebral development.
How similar studies have performed: Previous research has shown success in understanding developmental processes through similar approaches, particularly in model organisms like zebrafish and mice.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Ozbudak, Ertugrul M — Northwestern University at Chicago
- Study coordinator: Ozbudak, Ertugrul M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.