Understanding how cells form early in development to prevent birth defects
Molecular Interactions during Neural Crest Formation
This work explores how special cells called neural crest cells develop, which helps us understand conditions like birth defects and certain cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11136398 on NIH RePORTER |
What this research studies
Our bodies are built from many different types of cells, and some of the most important ones are called neural crest cells, which form very early in development. These cells travel throughout the body to create parts of our nervous system, skin color, and even bones in the face and head. When these cells don't form correctly, it can lead to a group of conditions known as Neurocristopathies, including common birth defects like cleft lip and palate, some aggressive cancers, and rare syndromes. This project aims to uncover the earliest signals that guide the formation of these crucial neural crest cells, focusing on how specific molecular pathways like TGFb/SMAD2-SMAD3 work.
Who could benefit from this research
Good fit: This foundational research is relevant to patients and families affected by Neurocristopathies, birth defects, or certain cancers linked to early developmental issues.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of how birth defects and other conditions arise, potentially paving the way for new ways to prevent or treat them.
How similar studies have performed: Other studies have identified key signaling pathways involved in neural crest formation, but this work aims to uncover the specific molecular details that remain largely unknown.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Garcia-Castro, Martin I. — University of California Riverside
- Study coordinator: Garcia-Castro, Martin I.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.