Understanding How Cells Fix DNA Damage to Prevent Cancer and Aging
Emerging Mechanisms of Replication-coupled DNA Repair
This research explores how our cells repair damage to their DNA, which is important for preventing diseases like cancer and conditions related to aging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11115661 on NIH RePORTER |
What this research studies
Our cells are constantly exposed to things that can harm their DNA, leading to mutations and other problems that contribute to cancer and aging. This project focuses on a specific type of severe DNA damage called interstrand cross-links (ICLs), which can block DNA replication. We are learning about the different ways cells fix these ICLs, including a newly discovered pathway that avoids creating more dangerous breaks in the DNA. Understanding these repair processes could lead to new ways to protect our bodies from disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future clinical applications may benefit individuals with cancer, aging-related conditions, or genetic disorders like Fanconi anemia.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how cancer and aging develop, potentially paving the way for new treatments or prevention strategies, especially for conditions like Fanconi anemia.
How similar studies have performed: Previous work has identified key pathways for DNA repair, and this project builds upon those findings by exploring emerging, alternative repair mechanisms.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Semlow, Daniel — California Institute of Technology
- Study coordinator: Semlow, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.