Understanding How Cells Fix Damaged DNA
Mechanistic Insights into Single-Strand Break Repair Within Chromatin
This research aims to understand how our cells repair common DNA damage, which is important for preventing diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11132678 on NIH RePORTER |
What this research studies
Our cells constantly face damage to their DNA, and fixing these breaks is vital for staying healthy. This project focuses on how cells repair the most common type of DNA damage, called single-strand breaks, using a specific repair pathway. Researchers are looking closely at the proteins and processes involved in this repair, including how certain molecules like PARP1 and PNKP work together. By understanding these detailed steps, we can learn more about why DNA repair sometimes fails, leading to serious health problems.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly but could eventually benefit individuals with cancers or neurological disorders linked to DNA repair issues.
Not a fit: Patients without conditions related to DNA repair mechanisms may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat diseases like cancer and neurological disorders by targeting DNA repair pathways.
How similar studies have performed: This research builds upon existing knowledge of DNA repair but seeks novel, detailed insights into specific repair mechanisms within the cell's structure.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Kim, Tae Hun — Case Western Reserve University
- Study coordinator: Kim, Tae Hun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.