Understanding How Cells Fight Viruses
Defining the Biology of the ADAR1-RISC Complex
This project explores a newly discovered way our cells protect themselves from viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11100040 on NIH RePORTER |
What this research studies
Our bodies have many ways to fight off viruses, and this project focuses on a recently found defense system that works differently from the well-known interferon response. Researchers are studying a specific protein called Drosha, which quickly moves to the cell's cytoplasm when a virus attacks. There, it teams up with other molecules to form a complex called ARC, which helps the cell defend itself. Understanding how this ARC complex works is key to finding new ways to combat viral infections.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this knowledge could seek individuals with specific viral infections.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could uncover new targets for developing antiviral medications or therapies to boost the body's natural defenses against infections.
How similar studies have performed: This project builds on recent discoveries about a novel defense system, suggesting it explores a relatively new and less understood area of antiviral biology.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Tenoever, Benjamin R. — New York University School of Medicine
- Study coordinator: Tenoever, Benjamin R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.