Understanding how cells fight off enteroviruses in children
Cell intrinsic antiviral mechanisms targeting human enteroviruses
This study is looking at how our bodies fight off enteroviruses, which can make kids very sick, and aims to find ways to boost those natural defenses to help protect young patients from these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10790008 on NIH RePORTER |
What this research studies
This research investigates the body's natural defenses against enteroviruses, which can cause serious illnesses in children, including acute flaccid myelitis. The team will identify specific genes that help cells resist these viruses and explore how these genes work to inhibit viral replication. By using advanced techniques, including gene delivery methods, they aim to enhance the antiviral response in laboratory models. The findings could lead to new strategies for preventing or treating enterovirus infections in young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are at risk for enterovirus infections or have experienced related illnesses.
Not a fit: Patients who are older than 11 years or those without a history of enterovirus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for enterovirus infections, potentially reducing severe outcomes in affected children.
How similar studies have performed: Previous research has shown promise in understanding antiviral mechanisms, but this specific approach targeting enteroviruses is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Schoggins, John W. — Ut Southwestern Medical Center
- Study coordinator: Schoggins, John W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.