Understanding how cells evolve and change over time
Cellular Phylogenetics and Evolution
This study is looking at how cells change over time by examining their genes closely, which could help patients understand how diseases develop and lead to better ways to diagnose and treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10808873 on NIH RePORTER |
What this research studies
This research focuses on the evolution of cells by using advanced sequencing techniques to analyze genetic variations within individual cells. By developing new methods to accurately reconstruct the evolutionary history of these cells, the project aims to address challenges posed by low mutation rates and sequencing errors. Patients may benefit from improved understanding of how diseases evolve at the cellular level, which could lead to better diagnostic and treatment strategies. The research will also create software tools for high-throughput analysis of cellular data, enhancing the ability to study genetic changes in various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve significant cellular evolution, such as cancer or infectious diseases.
Not a fit: Patients with stable, non-evolving conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate insights into cellular evolution, potentially improving disease diagnosis and treatment.
How similar studies have performed: Other research has shown promise in using advanced sequencing techniques for understanding cellular evolution, making this approach both innovative and relevant.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Miura, Sayaka — Temple Univ of the Commonwealth
- Study coordinator: Miura, Sayaka
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.