Understanding how cells enter a resting state
Systems biology of quiescence entry
This study looks at how cells, like those in our bodies, take a break when they’re stressed or low on nutrients, using baker's yeast to understand this process better, which could help us learn more about conditions like cancer and fibrosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10893407 on NIH RePORTER |
What this research studies
This research investigates the processes that lead cells to enter a state of quiescence, which is crucial for maintaining healthy cell function. By using advanced imaging techniques and computational analysis, the study aims to uncover how cells respond to stress and nutrient signals that trigger this resting state. The research focuses on a model organism, baker's yeast, to explore the molecular mechanisms involved in this decision-making process at a single-cell level. This approach could provide insights into disorders related to cell proliferation, such as cancer and fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cell proliferation disorders, such as cancer or fibrosis.
Not a fit: Patients with stable conditions that do not involve cell cycle dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases associated with abnormal cell growth.
How similar studies have performed: Other research has shown promise in understanding cellular quiescence, but this approach using advanced imaging and machine learning is relatively novel.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Argüello-Miranda, Orlando — North Carolina State University Raleigh
- Study coordinator: Argüello-Miranda, Orlando
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.