Understanding how cells ensure proper division during cell growth
Ins and Outs of Abscission Checkpoint Signaling: Molecular Mechanisms Safeguarding Abscission
This study is looking at how cells make sure they split correctly after dividing, which is important for preventing mistakes that can lead to cancer, and it aims to understand how energy levels in the cell might affect this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10913457 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control the final separation of cells after they divide, focusing on a specific checkpoint that prevents premature separation when chromosomes are not properly aligned. By using advanced techniques that combine structural studies and cell-based assays, the research aims to uncover how cells detect errors during division and how these errors can lead to DNA damage, which is often associated with cancer. The study will also explore how the cell's energy status influences the proteins involved in this checkpoint, potentially linking metabolism to cell division fidelity. This work could provide insights into the fundamental processes that safeguard against cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers related to chromosomal abnormalities or those at high risk for such conditions.
Not a fit: Patients with non-cancerous conditions unrelated to cell division or chromosomal integrity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer by improving our understanding of cell division errors.
How similar studies have performed: Other research has shown promising results in understanding cell cycle checkpoints and their implications for cancer, indicating that this approach has potential for success.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Wenzel, Dawn — Medical College of Wisconsin
- Study coordinator: Wenzel, Dawn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.