Understanding how cells ensure proper division during cell growth
Official title: Ins and Outs of Abscission Checkpoint Signaling: Molecular Mechanisms Safeguarding Abscission
Funded at Medical College of Wisconsin · NIH-10913457 · Data updated 2026-11-12
This study is looking at how cells make sure they split correctly after dividing, which is important for preventing mistakes that can lead to cancer, and it aims to understand how energy levels in the cell might affect this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $390,000 |
| NIH project number | 5R35GM150519-02 |
| Project ID | NIH-10913457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers related to chromosomal abnormalities or those at high risk for such conditions.
✕Less likely to help
Patients with non-cancerous conditions unrelated to cell division or chromosomal integrity may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the final separation of cells after they divide, focusing on a specific checkpoint that prevents premature separation when chromosomes are not properly aligned. By using advanced techniques that combine structural studies and cell-based assays, the research aims to uncover how cells detect errors during division and how these errors can lead to DNA damage, which is often associated with cancer. The study will also explore how the cell's energy status influences the proteins involved in this checkpoint, potentially linking metabolism to cell division fidelity. This work could provide insights into the fundamental processes that safeguard against cancer development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer by improving our understanding of cell division errors.
How similar studies have gone: Other research has shown promising results in understanding cell cycle checkpoints and their implications for cancer, indicating that this approach has potential for success.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Wenzel, Dawn — Medical College of Wisconsin
- Study coordinator: Wenzel, Dawn
Related research
Other NIH-funded projects on the same topics.
-
Finding a cure for sickle cell disease
The Cure Sickle Cell Initiative is bringing together patients, families, and caregivers to work together on finding a cure for sickle cell disease using safe genetic therapies, with the goal of improving lives and speeding up the development of new treatments.
-
A portable device to measure radiation dose and exposure uniformity after a large radiation event
A field-ready, nail-based device uses advanced spectroscopy and smart software to quickly estimate how much radiation a person has received and how evenly they were exposed, within minutes.
-
Ethics of Engaging Patient Groups in Drug Development for Rare Diseases
This grant asks how patient and family groups can ethically help shape rare-disease drug development from idea to market, with input from patients, families, doctors, and researchers.
-
Renovation of the Biophysics Resources at MCW
This grant funds upgrading a core biophysics facility at the Medical College of Wisconsin to support advanced research in human biology.
-
Cure Sickle Cell: Advancing Gene Therapies for Sickle Cell Disease
A national initiative to move safer genetic therapies for sickle cell disease forward with patient, caregiver, and advocate involvement.
-
Health insurance transitions for older adults with HIV on Medicare
Older adults with HIV face complex Medicare coverage that can affect access to HIV treatment and care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.