Understanding how cells ensure proper chromosome separation during division
Official title: Investigating the regulation and mechanism of tension-sensors Stu2 & Ndc80c
Funded at University of Utah · NIH-11035210 · Data updated 2026-11-12
This study is looking at how certain proteins help make sure chromosomes are properly divided during cell division, which is really important for keeping our genes healthy, and it's especially for people interested in understanding conditions like cancer that can happen when this process goes wrong.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | April 1, 2023 |
| Project end | April 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $14,886 |
| NIH project number | 5F31CA271740-03 |
| Project ID | NIH-11035210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals diagnosed with cancers characterized by aneuploidy.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers are not associated with aneuploidy may not benefit from this research.
What this research studies
This research investigates the mechanisms that ensure chromosomes are accurately separated during cell division, a process crucial for maintaining healthy genomes. The study focuses on specific proteins, Stu2 and Ndc80c, that play a role in sensing the forces acting on chromosomes as they attach to microtubules. By examining how these proteins function, the research aims to uncover the underlying causes of aneuploidy, a condition linked to various cancers. This work employs biochemical and biophysical methods to analyze the interactions and behaviors of these proteins in yeast cells, which serve as a model for understanding similar processes in humans.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with aneuploidy.
How similar studies have gone: Previous research has shown that understanding the mechanisms of chromosome segregation can lead to significant advancements in cancer treatment, indicating a promising avenue for this investigation.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Stewart, Michael — University of Utah
- Study coordinator: Stewart, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.