Understanding how cells ensure accurate chromosome separation during division
Mechanical activities ensuring accurate chromosome segregation
This study is looking at how a special protein complex helps ensure that chromosomes are divided correctly during cell division, which is important for preventing miscarriages and certain types of cancer, and it aims to understand how this complex senses forces and interacts with other structures to avoid mistakes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11089380 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind accurate chromosome segregation during cell division, which is crucial for preventing miscarriages and certain cancers. The study focuses on a protein complex called the kinetochore, which plays a key role in attaching chromosomes to spindle microtubules. By exploring how kinetochores sense mechanical forces and recognize microtubule structures, the research aims to uncover the underlying causes of errors in chromosome segregation. This could lead to a better understanding of the biological processes involved in cell division and their implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing miscarriages or those diagnosed with cancers linked to chromosome segregation errors.
Not a fit: Patients with conditions unrelated to chromosome segregation or those not experiencing miscarriages or related cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for conditions related to chromosome segregation errors, such as miscarriages and certain cancers.
How similar studies have performed: While the specific mechanisms of kinetochore function are still being explored, previous research has shown promising results in understanding chromosome segregation and its implications for cancer and reproductive health.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Miller, Matthew P — University of Utah
- Study coordinator: Miller, Matthew P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.