Understanding how cells ensure accurate chromosome division
Kinetochore Assembly and Regulation
This study looks at how cells divide and make sure their chromosomes are properly separated, using yeast to understand the teamwork involved in this process, which could help us find new ways to treat cancer by learning how cancer cells take advantage of these mechanisms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11112458 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromosome segregation during cell division, focusing on how kinetochores connect chromosomes to the spindle apparatus. By using the yeast Saccharomyces cerevisiae as a model organism, the study aims to uncover the cooperative processes involved in kinetochore assembly and regulation. The findings could provide insights into how cancer cells manipulate these processes for uncontrolled growth, potentially leading to new therapeutic strategies. The research employs biochemical assays and genetic analysis to explore these cellular mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include adults diagnosed with cancers that involve chromosomal abnormalities.
Not a fit: Patients with non-cancerous conditions or those under 21 years old may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by targeting the mechanisms that allow cancer cells to divide uncontrollably.
How similar studies have performed: Previous research has shown success in targeting chromosome segregation mechanisms in cancer cells, indicating that this approach has potential for significant advancements.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Zhou, Huilin — University of California, San Diego
- Study coordinator: Zhou, Huilin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.