Understanding How Cells Divide to Prevent Cancer
Mechanisms of Cytokinesis
This research explores the fundamental process of cell division, called cytokinesis, to understand how errors can lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11140497 on NIH RePORTER |
What this research studies
Our bodies are made of cells that constantly divide to grow and repair themselves, and cytokinesis is the final step where one cell splits into two. This project aims to uncover the precise molecular steps that control this division, focusing on how a special ring inside the cell helps it pinch apart. When cytokinesis doesn't happen correctly, cells can end up with too many chromosomes, which is a common first step in the development of many cancers. By understanding these basic mechanisms, we hope to find new ways to stop cancer from forming or growing.
Who could benefit from this research
Good fit: Patients who might benefit from future therapies developed from this basic science research include those at risk for or diagnosed with various types of cancer.
Not a fit: Patients will not receive direct benefit from this foundational laboratory research, as it does not involve clinical trials or direct patient intervention.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing or treating cancers by targeting the faulty cell division processes.
How similar studies have performed: Other studies have shown that errors in cell division are linked to cancer, and some existing cancer treatments target cell division processes.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Oegema, Karen F — University of California, San Diego
- Study coordinator: Oegema, Karen F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.