Understanding how cells divide properly
Mechanisms of Cytokinesis
This study is looking at how cells divide and what helps them split correctly, which is important because mistakes in this process can lead to cancer, and it aims to find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10886593 on NIH RePORTER |
What this research studies
This research investigates the process of cytokinesis, which is the final step of cell division where the contents of a mother cell are split into two daughter cells. It focuses on the mechanisms that ensure this division occurs accurately, particularly how signals from the mitotic spindle guide the formation of a contractile ring that helps in the separation. By studying these processes in detail, the research aims to uncover potential targets for new cancer therapies, as failures in cytokinesis can lead to cancerous cells. The approach involves examining the molecular signals that regulate this critical step in cell division.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers linked to cytokinesis failures or those at high risk for such conditions.
Not a fit: Patients with cancers unrelated to cytokinesis or those whose conditions do not involve cell division errors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or correct errors in cell division, potentially reducing cancer risk.
How similar studies have performed: Previous research has shown promising results in targeting cell division mechanisms for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Oegema, Karen F — University of California, San Diego
- Study coordinator: Oegema, Karen F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.