Understanding how cells divide differently to create various cell types in mammals
Revealing how the mitotic spindle controls asymmetric cell division in vivo
This study is looking at how cells divide in early mammal embryos and how tiny structures called microtubules help make sure that this division happens correctly, which is important for creating different types of cells needed for healthy development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10691246 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind asymmetric cell division in mammalian embryos, focusing on how microtubule organization influences this process. By using live imaging techniques, the study aims to observe how the mitotic spindle, which is crucial for cell division, operates in the early stages of mammalian development. The goal is to uncover how these divisions lead to the formation of diverse cell types, which is essential for proper development and function. This research could provide insights into fundamental biological processes that affect cell differentiation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals interested in developmental biology or those affected by conditions related to cell differentiation and fertility.
Not a fit: Patients with established cell differentiation disorders or those not involved in early developmental processes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of developmental biology and potentially lead to advancements in regenerative medicine and fertility treatments.
How similar studies have performed: While the mechanisms of asymmetric cell division have been studied in other organisms, this research aims to explore these processes specifically in mammalian embryos, making it a novel investigation.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Plachta, Nicolas Daniel — University of Pennsylvania
- Study coordinator: Plachta, Nicolas Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.