Understanding how cells divide correctly to prevent cancer
Ins and Outs of Abscission Checkpoint Signaling: Molecular Mechanisms Safeguarding Abscission
This project explores how cells make sure they divide properly, which is important for preventing cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11139469 on NIH RePORTER |
What this research studies
Our bodies are made of cells that constantly divide, and this process needs to be very precise. This project looks at a critical step in cell division called abscission, where two new cells finally separate. If this separation happens too early or incorrectly, it can lead to DNA damage and changes that are often seen in cancer. We are using advanced lab techniques to understand the safeguards cells have in place to ensure proper division, and how these safeguards might be affected by a cell's energy use.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit individuals affected by or at risk for various cancers in the future.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new ways to understand and potentially target the fundamental processes that contribute to cancer development.
How similar studies have performed: This project builds on existing knowledge of cell division and checkpoints, but it explores novel connections between cell metabolism and abscission checkpoint function.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Wenzel, Dawn — Medical College of Wisconsin
- Study coordinator: Wenzel, Dawn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.