Understanding how cells divide correctly
Official title: Mechanomolecular regulation of cell division
Funded at University of Massachusetts Amherst · NIH-11011170 · Data updated 2026-11-12
This study is looking at how cells divide correctly, which is really important for healthy growth and can help prevent problems like miscarriages and cancer, and it's for anyone interested in understanding how we can improve treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | January 23, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $438,629 |
| NIH project number | 1R35GM156188-01 |
| Project ID | NIH-11011170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing issues related to aneuploidy, such as miscarriages or certain types of cancer.
✕Less likely to help
Patients who do not have any conditions related to cell division errors or aneuploidy may not benefit from this research.
What this research studies
This research investigates the mechanisms that ensure accurate cell division, which is crucial for healthy development and preventing conditions like miscarriages and cancer. By using advanced imaging techniques and biochemical methods, the team will explore how specific proteins and microtubule behaviors contribute to the cell division process. The goal is to uncover the fundamental processes that can lead to better treatments for diseases caused by errors in cell division.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatments for conditions related to cell division errors, such as miscarriages and certain cancers.
How similar studies have gone: Other research has shown promise in understanding cell division mechanisms, but this specific approach combining live-cell imaging with biochemical analysis is relatively novel.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Maresca, Thomas Joseph — University of Massachusetts Amherst
- Study coordinator: Maresca, Thomas Joseph
Related research
Other NIH-funded projects on the same topics.
-
New England Center of Excellence in Vector-Borne Diseases (NEWVEC)
A center in New England will develop and test practical ways to prevent tick bites and reduce diseases from ticks, while training public health workers and engaging communities.
-
Understanding how minority stress affects cannabis use in sexual minorities
A research project follows young adult sexual minorities to see how daily stress and coping help explain cannabis use and related problems.
-
A non-contact way to measure stiffness in hydrogel scaffolds for tissue engineering
A new method uses 2D acoustic force elastography microscopy to measure how stiff hydrogel scaffolds are, without touching them, to help tissue engineering efforts.
-
Automated neural identification across species and development
A computer-driven project to map and track every neuron in molluscs’ brains as they grow and evolve, to better understand how brains stay organized over time.
-
Nanopore Tweezers to Study Kinase Movements and Find Allosteric Inhibitors in Cancers
A new technology uses nanopore tweezers to watch how cancer-related kinases move in real time and to screen for drugs that stop them by binding at sites away from the active site.
-
Promesa: Urban gardens and peer nutrition to help people with HIV in the Dominican Republic
A unified program uses urban gardening and peer nutrition counseling to help people living with HIV who are food insecure in the Dominican Republic improve their health and HIV outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.