Understanding how cells divide asymmetrically to create diverse cell types
Official title: Cell and mechanobiology of Asymmetric Cell Division
Funded at University of Washington · NIH-11016965 · Data updated 2026-11-12
This study is looking at how fruit fly brain cells decide what type of cell to become, focusing on how their size and physical surroundings play a role, and the results could help us understand similar processes in human cells that are important for growth and health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $339,310 |
| NIH project number | 5R35GM148160-03 |
| Project ID | NIH-11016965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the mechanisms of cell development and differentiation, particularly those affected by conditions related to stem cell function or cancer.
✕Less likely to help
Patients with conditions unrelated to cell division or differentiation may not receive direct benefits from this research.
What this research studies
This research investigates the process of Asymmetric Cell Division (ACD) in Drosophila neuroblasts, which are neural stem cells in fruit flies. By examining how mechanical cues and cell size differences influence cell fate decisions, the study aims to uncover the underlying mechanisms that generate diverse cell types necessary for tissue and organ development. Techniques such as RNA sequencing, immunohistochemistry, and live cell imaging will be employed to analyze these processes in real-time. The findings could provide insights into how similar mechanisms might operate in human cells, particularly in the context of development and disease.
Why it matters
Potential benefit: If successful, this research could lead to advancements in regenerative medicine and cancer treatment by enhancing our understanding of cell differentiation.
How similar studies have gone: Other research has shown success in understanding cell division and differentiation, making this approach promising and building on established knowledge.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Clemens C. Cabernard, Clemens C — University of Washington
- Study coordinator: Clemens C. Cabernard, Clemens C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.