Understanding how cells divide and take shape
Spatial and temporal control of Rho family GTPases
This project explores how tiny switches inside cells control their growth and organization, which could help us understand conditions like cancer and birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11135482 on NIH RePORTER |
What this research studies
Our bodies are made of countless cells that constantly divide and organize themselves to form tissues and organs. This project looks closely at special proteins, called small GTPases, that act like tiny switches on cell membranes, guiding these fundamental processes. By studying these switches in simple organisms like worms and fruit flies, we aim to uncover the basic rules that govern how cells grow, divide, and take their proper shape. This foundational knowledge is crucial because errors in these processes can lead to serious health issues.
Who could benefit from this research
Good fit: Patients interested in the basic biological mechanisms underlying conditions like cancer and birth defects may find this foundational research relevant to their understanding.
Not a fit: Patients seeking immediate new treatments or direct clinical trial participation will not find this basic science project directly applicable.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into the cellular malfunctions that contribute to certain cancers and the development of some birth defects.
How similar studies have performed: This project builds upon extensive prior research into cell biology and signaling pathways, using advanced techniques to explore fundamental questions in new ways.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Glotzer, Michael a. — University of Chicago
- Study coordinator: Glotzer, Michael a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.