Understanding how cells divide and segregate chromosomes
Emergent mechanics of mammalian chromosome segregation
This study is looking at how cells make sure they split their genetic material correctly during division, using special tools to see how different forces affect the parts of the cell that help with this process, and it's aimed at anyone interested in understanding how our cells work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11091072 on NIH RePORTER |
What this research studies
This research investigates the mechanics of chromosome segregation during cell division, focusing on the spindle and kinetochore, which are essential for ensuring that daughter cells inherit the correct genetic material. By using advanced techniques like microneedle manipulation, the researchers aim to apply controlled forces to live mammalian cells and observe how these forces affect the physical properties and functions of the spindle and kinetochore. The study combines physical and molecular perturbations with imaging and modeling to gain insights into the complex interactions that drive chromosome movement and attachment during cell division.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers related to chromosome segregation errors.
Not a fit: Patients with conditions unrelated to chromosome segregation or those who are not undergoing cell division-related therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the mechanisms behind birth defects and cancer, potentially informing new therapeutic strategies.
How similar studies have performed: Other research has shown success in understanding cellular mechanics, but this approach of combining mechanical perturbations with live imaging is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Dumont, Sophie — University of California, San Francisco
- Study coordinator: Dumont, Sophie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.