Understanding how cells differentiate and form new blood vessels
Network models of differentiation landscapes for angiogenesis and hematopoiesis
This study is looking at how cells change into different types, especially in forming blood vessels, to help find new ways to treat diseases like cancer and eye problems as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10913969 on NIH RePORTER |
What this research studies
This research aims to develop mathematical models that help explain how cells differentiate into various types, particularly in the context of blood vessel formation and related conditions. By using advanced techniques like single-cell transcriptomics, the researchers will simulate how changes in gene expression affect cell behavior. This approach not only seeks to uncover fundamental biological processes but also aims to identify potential new drug targets for treating diseases like cancer and age-related macular degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by age-related macular degeneration, certain cancers, or other conditions involving abnormal blood vessel growth.
Not a fit: Patients with conditions unrelated to blood vessel formation or cell differentiation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve treatment outcomes for patients with conditions related to blood vessel formation and differentiation.
How similar studies have performed: Previous research using mathematical modeling in biological systems has shown promise, indicating that this approach could yield valuable insights and breakthroughs.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Piermarocchi, Carlo — Michigan State University
- Study coordinator: Piermarocchi, Carlo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.