Understanding how cells differentiate and form new blood vessels
Official title: Network models of differentiation landscapes for angiogenesis and hematopoiesis
Funded at Michigan State University · NIH-10913969 · Data updated 2026-11-12
This study is looking at how cells change into different types, especially in forming blood vessels, to help find new ways to treat diseases like cancer and eye problems as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $376,057 |
| NIH project number | 5R35GM149261-02 |
| Project ID | NIH-10913969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals affected by age-related macular degeneration, certain cancers, or other conditions involving abnormal blood vessel growth.
✕Less likely to help
Patients with conditions unrelated to blood vessel formation or cell differentiation may not benefit from this research.
What this research studies
This research aims to develop mathematical models that help explain how cells differentiate into various types, particularly in the context of blood vessel formation and related conditions. By using advanced techniques like single-cell transcriptomics, the researchers will simulate how changes in gene expression affect cell behavior. This approach not only seeks to uncover fundamental biological processes but also aims to identify potential new drug targets for treating diseases like cancer and age-related macular degeneration.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve treatment outcomes for patients with conditions related to blood vessel formation and differentiation.
How similar studies have gone: Previous research using mathematical modeling in biological systems has shown promise, indicating that this approach could yield valuable insights and breakthroughs.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Piermarocchi, Carlo — Michigan State University
- Study coordinator: Piermarocchi, Carlo
Related research
Other NIH-funded projects on the same topics.
-
Understanding how octopuses integrate sensory information and make decisions
This study is exploring how octopuses use their arms to grip things by looking closely at their nervous system and movements, which could help us understand their amazing abilities better.
-
Stabilizing the tear film to relieve evaporative dry eye
This project tests new ways to stabilize the tear film in people with evaporative dry eye, with the goal of longer-lasting comfort.
-
Cell-type specific brain stimulation: new methods to map and predict ICMS effects
A study using targeted brain stimulation and advanced gene mapping to understand how different brain cell types respond to electrical stimulation and how this affects behavior.
-
Expanded program to monitor work injuries and illnesses in Michigan
A nationwide-style occupational health surveillance program will be continued and expanded in Michigan to track injuries, illnesses, and related hazards among workers.
-
Identifying protective antibody responses to malaria in children
Young children in Africa may develop antibodies that protect against malaria; this project maps which antibody features help prevent severe disease.
-
Understanding how viral fusion proteins cause membranes to fuse
Scientists are studying how the envelope proteins of AIDS-causing viruses help them fuse with human cells, with the aim of guiding new antiviral strategies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.