Understanding how cells die during cell division delays
Official title: Parameters that determine cell fate during mitotic arrest
Funded at New Mexico State University Las Cruces · NIH-11057702 · Data updated 2026-11-12
This study is looking at how delays in cell division can cause cancer cells to die, especially by using certain drugs that affect this process, with the hope of finding better ways to treat cancer and help patients respond more effectively to their therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New Mexico State University Las Cruces NIH-funded |
| Lab location | 1 site (Las Cruces, United States) |
| Project start | May 10, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $143,997 |
| NIH project number | 5R16GM145387-04 |
| Project ID | NIH-11057702 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with aggressive and hormone-independent cancers who are undergoing treatment with anti-mitotic drugs.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers do not involve mitotic spindle disruption may not benefit from this research.
What this research studies
This research investigates the mechanisms behind cell death when cells experience delays during division, particularly focusing on the role of the spindle assembly checkpoint. It utilizes advanced imaging techniques and biochemical methods to explore how certain drugs, which disrupt normal cell division, can lead to more consistent cell death responses in cancer cells. By targeting specific proteins and signaling pathways, the research aims to enhance the effectiveness of existing cancer therapies. Patients may benefit from a better understanding of how their cancer cells respond to treatment, potentially leading to improved therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that result in higher rates of cancer cell death.
How similar studies have gone: Previous research has shown promising results in targeting the mitotic spindle for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
New Mexico State University Las Cruces
Las Cruces, United States Active
Researchers
- Principal investigator: Shuster, Charles Bradley — New Mexico State University Las Cruces
- Study coordinator: Shuster, Charles Bradley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.