Understanding how cells die during cell division delays
Parameters that determine cell fate during mitotic arrest
This study is looking at how delays in cell division can cause cancer cells to die, especially by using certain drugs that affect this process, with the hope of finding better ways to treat cancer and help patients respond more effectively to their therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New Mexico State University Las Cruces NIH-funded |
| Lab location | 1 site (Las Cruces, United States) |
| Project ID | NIH-11057702 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cell death when cells experience delays during division, particularly focusing on the role of the spindle assembly checkpoint. It utilizes advanced imaging techniques and biochemical methods to explore how certain drugs, which disrupt normal cell division, can lead to more consistent cell death responses in cancer cells. By targeting specific proteins and signaling pathways, the research aims to enhance the effectiveness of existing cancer therapies. Patients may benefit from a better understanding of how their cancer cells respond to treatment, potentially leading to improved therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with aggressive and hormone-independent cancers who are undergoing treatment with anti-mitotic drugs.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve mitotic spindle disruption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that result in higher rates of cancer cell death.
How similar studies have performed: Previous research has shown promising results in targeting the mitotic spindle for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Las Cruces, United States
- New Mexico State University Las Cruces — Las Cruces, United States (Active)
Researchers
- Principal investigator: Shuster, Charles Bradley — New Mexico State University Las Cruces
- Study coordinator: Shuster, Charles Bradley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.