Understanding how cells die and survive in cancer
MECHANISMS OF REGULATED CELL DEATH
This study is looking at how some cancer cells manage to survive even when they should be dying from treatments, and it aims to find new ways to help make those cells more vulnerable to therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10982340 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of regulated cell death, focusing on processes like apoptosis and necroptosis, which are crucial for understanding cancer progression. The team aims to uncover how certain cells can evade death and survive despite being exposed to treatments that typically induce cell death. By studying these 'flatliner' cells, which resist apoptosis, the research seeks to identify pathways that contribute to cancer cell aggressiveness and treatment resistance. The findings could lead to new strategies for targeting these survival mechanisms in cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with cancers that exhibit resistance to standard treatments due to evasion of cell death mechanisms.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve regulated cell death mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by targeting the mechanisms that allow cancer cells to survive and resist therapies.
How similar studies have performed: Previous research has shown success in understanding cell death mechanisms in cancer, making this approach a continuation of established findings rather than a completely novel endeavor.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Green, Douglas R. — St. Jude Children's Research Hospital
- Study coordinator: Green, Douglas R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.