Understanding how cells develop and specialize in the body
Epigenetic Regulation of Lineage Specification
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10849786
This study is looking at how cells in our bodies become different types, even though they all have the same DNA, and it’s for anyone interested in understanding how our cells develop properly and how this knowledge might help with diseases that happen when cells don’t develop correctly.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10849786 on ClinicalTrials.gov |
What this research studies
This research investigates how cells in multicellular organisms differentiate into specialized types, despite sharing the same genetic material. It focuses on the role of epigenetic factors, which modify DNA and influence gene expression, in guiding this process. By studying how certain proteins can remove chemical modifications from DNA, the research aims to uncover mechanisms that ensure proper cell development and function. This knowledge could help address diseases caused by errors in cell lineage specification.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or developmental syndromes related to cell lineage specification.
Not a fit: Patients with conditions unrelated to cell differentiation or those not affected by epigenetic regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers and developmental disorders linked to improper cell differentiation.
How similar studies have performed: Other research has shown promising results in understanding epigenetic regulation and its impact on cell differentiation, indicating that this approach has potential for success.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSANGARATOU, AGELIKI — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: TSANGARATOU, AGELIKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers