Understanding how cells decide their fate using synthetic biology and computer models
Reprogramming cell-fate decisions through predictive modeling and synthetic biology
This study looks at how yeast cells decide what to do when they get damaged, using a mix of biology and computer modeling to understand the different paths they can take, which might help us learn more about how our own cells behave in similar situations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11093083 on NIH RePORTER |
What this research studies
This research investigates how cells, specifically yeast cells, make decisions about their fate when faced with damage or deterioration. By combining synthetic biology with computational modeling, the team aims to understand the complex interactions of genes that influence these decisions. The study focuses on two distinct pathways that genetically identical cells can take as they approach death, exploring how these pathways are influenced by various factors. This approach allows for a detailed examination of cellular processes that could have implications for understanding similar mechanisms in human cells.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions related to cell damage, such as cancer or degenerative neurologic disorders.
Not a fit: Patients with acute conditions that do not involve cellular deterioration or damage may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing cell damage and deterioration in various diseases, including cancers and degenerative disorders.
How similar studies have performed: While this approach is innovative, similar studies in other organisms have shown promise in understanding cell fate decisions, suggesting potential for success in this novel application.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Hao, Nan — University of California, San Diego
- Study coordinator: Hao, Nan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.