Understanding how cells decide their fate using advanced modeling and biology tools
Reprogramming cell-fate decisions through predictive modeling and synthetic biology
This project aims to understand how cells decide between different paths of damage and deterioration, which could offer new insights into conditions like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11170403 on NIH RePORTER |
What this research studies
Our bodies are made of cells, and sometimes these cells get damaged or deteriorate, which is a key part of many diseases, including cancer. This project uses advanced tools from synthetic biology and computational modeling to explore how cells make critical decisions about their fate. By studying yeast cells, which share many basic biological processes with human cells, we can learn how genes interact and change over time to influence cell damage and deterioration. The goal is to uncover the fundamental rules that govern these cell-fate decisions, helping us understand why cells sometimes go down harmful paths.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit individuals affected by diseases involving cell damage and deterioration, such as cancers.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge about cell damage and deterioration, potentially leading to new strategies for preventing or treating diseases like cancer in the future.
How similar studies have performed: This project builds on recent discoveries about cell deterioration pathways in yeast and leverages established synthetic biology and computational modeling techniques.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Hao, Nan — University of California, San Diego
- Study coordinator: Hao, Nan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.