Understanding how cells decide their fate using advanced computer models
Computational Modeling of Lineage Decisions using Single-cell Data
This study is exploring how cells change and specialize from a single cell into different types, which could help us understand diseases related to this process and ultimately improve patient care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10889170 on NIH RePORTER |
What this research studies
This research investigates the complex process of cellular differentiation, where cells develop from single-cell embryos into specialized cells. By utilizing advanced single-cell RNA sequencing technologies and developing new algorithms, the project aims to model and interpret how cells make lineage decisions based on their microenvironment. The approach involves analyzing various datasets to uncover the mechanisms behind these decisions and the asymmetries that may influence them. Patients may benefit from insights gained that could lead to improved understanding of diseases related to cell differentiation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to abnormal cell differentiation or those involved in studies of cellular processes.
Not a fit: Patients with conditions unrelated to cellular differentiation or those not involved in relevant biological processes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular behavior, potentially leading to new treatments for diseases linked to cell differentiation.
How similar studies have performed: Other research has shown success in utilizing single-cell sequencing technologies to understand cellular processes, indicating that this approach has a strong foundation.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Setty, Manu N — Fred Hutchinson Cancer Center
- Study coordinator: Setty, Manu N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.