Understanding how cells decide their fate during early development
Official title: Molecular recording to understand the determinants of cell fate transitions in early development
Funded at Sloan-Kettering Inst Can Research · NIH-11056874 · Data updated 2026-11-12
This study is looking at how a single cell can turn into different types of cells in mammals, using new techniques to watch this process happen in real-time, which could help us learn more about development and improve treatments in regenerative medicine.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HG012973-03 |
| Project ID | NIH-11056874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in advancements in regenerative medicine and developmental biology, particularly those affected by conditions related to cell differentiation.
✕Less likely to help
Patients with established conditions that do not involve cellular development or differentiation may not benefit from this research.
What this research studies
This research investigates the mechanisms that determine how a single cell develops into various specialized cell types during mammalian development. By using innovative molecular recording techniques, the study aims to observe and document cellular events continuously and non-destructively. This approach allows researchers to track cell lineage and key signaling events in real-time, providing insights into the processes that guide cell fate decisions. The findings could enhance our understanding of developmental biology and have implications for regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine by improving our understanding of how to manipulate cell fate for therapeutic purposes.
How similar studies have gone: Other research has shown promise with similar molecular recording techniques, indicating potential for success in this novel approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Choi, Junhong — Sloan-Kettering Inst Can Research
- Study coordinator: Choi, Junhong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.