Understanding how cells decide their fate based on environmental signals
Epigenesis of Cell Fate Potential
This study is looking at how T cells, a type of immune cell, make decisions about their roles in the body based on different signals they receive, and it aims to understand how changes in the way DNA is organized can affect these decisions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11132266 on NIH RePORTER |
What this research studies
This research investigates how cells, particularly T cells, respond to various environmental and developmental cues to determine their fate. By focusing on the regulation of chromatin, which is the structure that organizes DNA, the study aims to uncover the molecular mechanisms that guide these cellular decisions. The researchers will explore how chromatin remodeling complexes, which modify DNA accessibility, influence gene activity and cellular identity during T cell development. This work could provide insights into the fundamental processes that govern cell function and adaptation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those interested in understanding T cell biology.
Not a fit: Patients with non-autoimmune conditions or those not interested in cellular biology may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating T cell responses in autoimmune diseases and other conditions.
How similar studies have performed: Other research has shown promising results in understanding cellular decision-making processes, particularly in T cells, indicating that this approach has potential for significant insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Koh, Andrew S — University of Chicago
- Study coordinator: Koh, Andrew S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.