Understanding how cells decide their fate based on environmental signals
Epigenesis of Cell Fate Potential
['FUNDING_OTHER'] · UNIVERSITY OF CHICAGO · NIH-10883681
This study looks at how T cells, a type of immune cell, make decisions about their roles in the body based on different signals they receive, and it aims to understand how the structure of DNA helps guide these important choices.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10883681 on ClinicalTrials.gov |
What this research studies
This research investigates how cells, particularly T cells, respond to various developmental and environmental cues to determine their fate. By focusing on the regulation of chromatin, which is the structure that organizes DNA, the study aims to uncover the molecular mechanisms that guide these cellular decisions. The researchers utilize a model system of T cells, which are well-characterized and readily available, to explore how chromatin remodeling complexes influence gene activity and cellular identity. The ultimate goal is to define the biological processes that establish and maintain the potential for specific cellular responses.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autoimmune conditions or those interested in cellular therapies.
Not a fit: Patients with stable, non-autoimmune conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how to manipulate cell fate, potentially improving treatments for autoimmune diseases and other conditions.
How similar studies have performed: Other research has shown promising results in understanding cellular decision-making processes, making this approach both relevant and potentially impactful.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOH, ANDREW S — UNIVERSITY OF CHICAGO
- Study coordinator: KOH, ANDREW S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.