Understanding how cells create organelles at the endoplasmic reticulum
MECHANISMS OF ORGANELLE BIOGENESIS AT THE ENDOPLASMIC RETICULUM SUBDOMAINS
This study is looking at how cells create different parts, especially focusing on a structure called the endoplasmic reticulum, to learn more about how they make important components like peroxisomes and lipid droplets, which could help us understand certain health issues related to cell function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project ID | NIH-10870151 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells generate different organelles, focusing on the endoplasmic reticulum (ER) and its specialized subdomains. By using yeast and mammalian cell cultures, the study aims to characterize these ER subdomains and their role in the formation of peroxisomes and lipid droplets. The researchers will identify specific proteins and lipids associated with these subdomains to better understand organelle biogenesis. This work could provide insights into cellular functions and disorders related to organelle dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to organelle dysfunction, such as adult-onset diabetes mellitus or fatty liver disease.
Not a fit: Patients with organelle-related disorders that are not linked to the endoplasmic reticulum may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to organelle dysfunction, such as diabetes and fatty liver disease.
How similar studies have performed: While the specific focus on ER subdomains is novel, previous research has shown success in understanding organelle biogenesis in other contexts.
Where this research is happening
Knoxville, United States
- University of Tennessee Knoxville — Knoxville, United States (Active)
Researchers
- Principal investigator: Joshi, Amit — University of Tennessee Knoxville
- Study coordinator: Joshi, Amit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.