Understanding how cells create new membrane structures
Official title: Mechanisms of de novo membrane assembly
Funded at State University New York Stony Brook · NIH-10986998 · Data updated 2026-11-12
This study looks at how cells create new compartments by moving tiny bubbles called vesicles around, which is important for how cells work and develop, and it aims to help us understand how problems in this process might lead to diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $282,257 |
| NIH project number | 5R01GM145606-03 |
| Project ID | NIH-10986998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cellular dysfunction or diseases associated with defects in membrane assembly.
✕Less likely to help
Patients with conditions unrelated to cellular membrane processes may not receive any benefit from this research.
What this research studies
This research investigates the fundamental processes by which cells rearrange vesicular traffic to form new membrane compartments, which are crucial for various cellular functions and differentiation. It focuses on two key examples: the formation of autophagosomes and the ciliary sheath, both of which involve the coalescence of vesicles on a protein substrate. By studying the mechanisms involved in these processes, particularly in budding yeast, the research aims to uncover the molecular details that govern membrane assembly and expansion. This could provide insights into how defects in these processes contribute to various diseases.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cellular processes that are critical for health, potentially informing new treatments for diseases linked to membrane assembly defects.
How similar studies have gone: Previous research has shown success in understanding cellular processes through model systems like budding yeast, indicating that this approach is promising.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Neiman, Aaron M — State University New York Stony Brook
- Study coordinator: Neiman, Aaron M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.