Understanding how cells create and maintain peroxisomes
Investigating the mechanisms of peroxisome homeostasis
This study is looking at how certain proteins help cells create and maintain tiny structures called peroxisomes, which are important for our metabolism, to better understand genetic disorders and aging that can affect these organelles.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Barbara NIH-funded |
| Lab location | 1 site (Santa Barbara, United States) |
| Project ID | NIH-11081538 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells produce and sustain peroxisomes, which are essential organelles involved in various metabolic processes. The study employs protein biochemistry and yeast cell biology techniques to explore the roles of specific proteins, particularly focusing on the Pex1/Pex6 proteins that are crucial for peroxisome formation. By examining how these proteins function and interact with other cellular components, the research aims to uncover insights that could improve our understanding of genetic disorders related to peroxisome dysfunction and the aging process.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with rare genetic Peroxisome Biogenesis Disorders (PBDs) or those experiencing age-related metabolic issues.
Not a fit: Patients without any genetic disorders related to peroxisome function or those not experiencing metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for genetic disorders associated with peroxisome dysfunction.
How similar studies have performed: While the specific mechanisms of peroxisome homeostasis are still being explored, related research has shown promise in understanding cellular organelle functions and their implications for human health.
Where this research is happening
Santa Barbara, United States
- University of California Santa Barbara — Santa Barbara, United States (Active)
Researchers
- Principal investigator: Gardner, Brooke Meghan — University of California Santa Barbara
- Study coordinator: Gardner, Brooke Meghan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.