Understanding How Cells Copy Their DNA to Prevent Cancer and Other Diseases
Cell Cycle Dynamics that Ensure Genome Maintenance
This research helps us understand how human cells accurately copy their DNA, which is crucial for preventing diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11126689 on NIH RePORTER |
What this research studies
This research explores the basic ways human cells divide and make copies of their DNA. When cells don't copy their DNA correctly, it can lead to problems like cancer, developmental issues, and aging-related conditions. Our bodies rely on a precise process called "origin licensing" to ensure DNA is copied completely and efficiently. This project aims to uncover the mysteries of how this licensing process is controlled, especially in different cell types and situations. By gaining a deeper understanding, we hope to find new ways to diagnose and treat diseases where cell growth goes wrong.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals affected by cancers, developmental defects, or degenerative diseases linked to cell division errors.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to diagnose and treat conditions like cancer and developmental disorders by better understanding how cells grow and divide.
How similar studies have performed: While the specific mechanisms of origin licensing are still being uncovered, extensive basic science has shown that understanding fundamental cell processes is critical for developing future therapies.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Cook, Jeanette Gowen — Univ of North Carolina Chapel Hill
- Study coordinator: Cook, Jeanette Gowen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.