Understanding how cells copy their DNA to prevent cancer
Molecular mechanism of eukaryotic chromosome replication
This project explores how our cells accurately copy their DNA, which is vital for preventing diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11163211 on NIH RePORTER |
What this research studies
This project aims to understand the precise molecular steps our cells take to copy their DNA, a process that, when flawed, can lead to genome instability and diseases like cancer. Researchers are building a system using purified proteins from yeast and human cells to mimic this DNA copying process in the lab. This allows them to observe how DNA replication works normally and how it responds to challenges or 'stress' that can cause errors. By gaining a deeper understanding of these fundamental mechanisms, we hope to uncover new ways to protect our cells from damage that contributes to cancer development.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation, but future clinical applications would be relevant to individuals at risk for or living with cancer.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge that leads to new insights into how cancer develops and potentially new strategies for its prevention or treatment.
How similar studies have performed: While the specific reconstituted human protein system is a novel approach, the fundamental understanding of DNA replication mechanisms has been built upon decades of successful basic science research.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Remus, Dirk — Sloan-Kettering Inst Can Research
- Study coordinator: Remus, Dirk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.