Understanding How Cells Copy Their DNA
Initiation of DNA Replication at Cell Origins in Yeast
This research helps us understand how cells make exact copies of their DNA, which is vital for preventing diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11088792 on NIH RePORTER |
What this research studies
Our bodies are made of tiny cells that constantly divide and make copies of their DNA. This project looks at how cells start this copying process, focusing on the precise steps involved. When DNA copying goes wrong, it can lead to serious problems like cancer or genetic disorders. By understanding these basic steps, we hope to find new ways to identify and treat diseases where cell growth is out of control. We are studying this process in yeast and human cells to learn how it works across different living things.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually benefit patients with cancer or genetic disorders.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose and treat cancers and other diseases caused by errors in DNA copying.
How similar studies have performed: While the specific mechanisms of origin specification in diverse eukaryotes are still being uncovered, significant progress has been made in understanding DNA replication initiation in yeast.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Stillman, Bruce W. — Cold Spring Harbor Laboratory
- Study coordinator: Stillman, Bruce W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.