Understanding how cells copy genetic information to prevent diseases like cancer
Investigating the roles of the H3.1-TSK/TONSL pathway during chromatin replication
This research helps us understand how our cells accurately copy their genetic material, which is crucial for preventing diseases like cancer and neurodegenerative disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11139470 on NIH RePORTER |
What this research studies
Our cells constantly copy their genetic information, a process called chromatin replication, to pass it on to new cells. If this copying goes wrong, it can lead to changes in our genes that cause serious illnesses, including cancer and brain disorders. We are looking closely at how specific parts of our cells, like the H3.1-TSK/TONSL system, help repair DNA during this copying process. By understanding how this system works, we hope to find new ways to protect our genetic material from damage and maintain genomic stability.
Who could benefit from this research
Good fit: This foundational research is relevant for anyone interested in the basic cellular mechanisms that contribute to diseases like cancer and neurodegenerative disorders.
Not a fit: Patients seeking immediate new treatments or direct clinical trial participation would not find direct benefit from this basic science research at this stage.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat diseases like cancer and neurodegenerative disorders by ensuring our cells copy their genetic information correctly.
How similar studies have performed: This research builds upon recent discoveries by the same group, identifying a novel mechanism involving H3.1 and TSK/TONSL in DNA repair.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Jacob, Yannick — Yale University
- Study coordinator: Jacob, Yannick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.