Understanding how cells copy DNA and deal with damage
Bypass Mechanisms in Eukaryotic Replication
This study is looking at how cells copy their DNA and deal with problems that can cause damage, which is important for understanding diseases like cancer, and it’s for anyone interested in how our bodies keep our genetic information safe.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-10900766 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells replicate their DNA and how they manage obstacles that can cause damage during this process. The team will use advanced techniques to recreate the DNA copying machinery in the lab and study how it maintains genetic integrity while overcoming challenges. By examining the interactions of various proteins involved in DNA replication, the research aims to uncover insights that could lead to better treatments for diseases like cancer caused by DNA damage. The approach combines biochemistry, single-molecule biophysics, and structural biology to provide a comprehensive understanding of these critical cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals at risk for or diagnosed with cancers linked to chromosomal instability.
Not a fit: Patients with conditions unrelated to DNA replication or damage mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers related to DNA damage.
How similar studies have performed: Other research has shown success in understanding DNA damage response mechanisms, indicating that this approach has potential for significant findings.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Schauer, Grant — Colorado State University
- Study coordinator: Schauer, Grant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.