Understanding how cells copy and maintain their DNA
Mechanisms of DNA replication and maintenance in eukaryotes
This project explores the fundamental ways our cells make copies of their DNA and fix any mistakes, which is key to understanding diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11106011 on NIH RePORTER |
What this research studies
Our cells constantly copy their DNA, and sometimes errors happen or damage occurs. This project looks closely at how cells manage this copying process and repair any issues, focusing on the fundamental steps involved. We use yeast as a model to understand these complex processes, including how cells respond to DNA damage and prevent mutations. By studying these basic mechanisms, we hope to learn more about what goes wrong in diseases where DNA is damaged or copied incorrectly, such as cancer.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this knowledge could benefit individuals with conditions related to DNA damage and replication errors, such as certain cancers.
Not a fit: Patients seeking immediate clinical treatments or direct participation in human trials will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge about DNA replication and repair that may lead to new ways to prevent or treat diseases like cancer.
How similar studies have performed: This project builds upon a strong history of research into DNA replication mechanisms, using established biochemical and genetic approaches.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Burgers, Peter M — Washington University
- Study coordinator: Burgers, Peter M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.