Understanding how cells control their volume in zebrafish
Official title: Investigating mechanisms of cell volume regulation in the zebrafish notochord
Funded at Duke University · NIH-11061227 · Data updated 2026-11-12
This study is looking at how zebrafish cells control their size and shape by managing the flow of fluids, which could help us understand important processes in growth and development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $393,906 |
| NIH project number | 5R01GM150666-02 |
| Project ID | NIH-11061227 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions that affect cell volume regulation or related developmental issues.
✕Less likely to help
Patients with conditions unrelated to cell volume regulation or those not experiencing developmental issues may not benefit from this research.
What this research studies
This research investigates how animal cells, specifically in zebrafish, regulate their volume through ion channels that manage osmotic processes. The study aims to uncover the mechanisms that allow cells to maintain proper volume and coordinate this regulation across different tissues and organs. By employing a combination of genetic, cell biological, physiological, and quantitative methods, researchers will explore how fluid transport and cell volume are influenced by mechanical signals. This could provide insights into fundamental biological processes that are crucial for development.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cell volume regulation, potentially leading to new treatments for conditions related to cell volume dysregulation.
How similar studies have gone: While the specific mechanisms being investigated may be novel, previous research has shown success in understanding cell volume regulation through similar biological approaches.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Bagnat, Michel — Duke University
- Study coordinator: Bagnat, Michel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.